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The Epigenetics Revolution: How Modern Biology is Rewriting our Understanding of Genetics, Disease and Inheritance (English Edition) Libro di eccezionale interesse Per me che ho studiato scienze negli anni 50 e che , comunque nuovo avevo ottenuto qualche informazione su DNA , stata la scoperta di un mondo completamente La descrizione dei processi dinamici che regolano la utilizzazione delle informazioni del DNA fantastica E da tenere presente che , a mio avviso, non un libro di lettura ma un testo che va studiato con impegno e pazienza.I risultati , oltre ad un fatto di comprensione di come si formano e come funzionano le nostre cellule ed i nostri organi , riguardano direttamente il nostro modo di comportarci e di alimentarci.Grande libro. A Book That Would Have Had Darwin Swooning Anyone Seriously Interested In Who We Are And How We Function Should Read This GuardianAt The Beginning Of This Century Enormous Progress Had Been Made In Genetics The Human Genome Project Finished Sequencing Human DNA It Seemed It Was Only A Matter Of Time Until We Had All The Answers To The Secrets Of Life On This PlanetThe Cutting Edge Of Biology, However, Is Telling Us That We Still Don T Even Know All Of The QuestionsHow Is It That, Despite Each Cell In Your Body Carrying Exactly The Same DNA, You Don T Have Teeth Growing Out Of Your Eyeballs Or Toenails On Your Liver How Is It That Identical Twins Share Exactly The Same DNA And Yet Can Exhibit Dramatic Differences In The Way That They Live And Grow It Turns Out That Cells Read The Genetic Code In DNA Like A Script To Be Interpreted Than A Mould That Replicates The Same Result Each Time This Is Epigenetics And It S The Fastest Moving Field In Biology TodayThe Epigenetics Revolution Traces The Thrilling Path This Discipline Has Taken Over The Last Twenty Years Biologist Nessa Carey Deftly Explains Such Diverse Phenomena As How Queen Bees And Ants Control Their Colonies, Why Tortoiseshell Cats Are Always Female, Why Some Plants Need A Period Of Cold Before They Can Flower, Why We Age, Develop Disease And Become Addicted To Drugs, And Much Most Excitingly, Carey Reveals The Amazing Possibilities For Humankind That Epigenetics Offers For Us All And In The Surprisingly Near Future Questo libro fornisce un ottima e completa introduzione all epigenetica e lo consiglio a tutti quelli che desiderano avere una visione di insieme di questa affascinante scienza Non servono conoscenze biologiche di base ma dal mio punto di vista la lettura risulta molto facilitata e piacevole se non si deve cercare di approfondire ogni concetto che viene introdotto Ho letto questo libro per prepararmi a un corso on line di epigenetica e mi davvero servito molto per rafforzare i concetti appresi e chiarire punti meno facili. The issue itself is quite complicated, but the author manages to develop it in a complete and well understandable way It s one of the best books I ve red in the last months If you are looking for a comprehensive introduction to the science of epigentics, this will serve you well It was a relatively easy and enjoyable read.The criticism of its intended audience being unclear is fair At times, it seems to be aimed at a rather lay audience with slightly odd analogies that over simplify almost to a fault A few pages later, jargon and technicalities are tossed around that definitely require a solid background in biology to follow with any ease This has the discordant effect of making the simplistic analogies seem even odd It can t seem to decide if it expects you to remember only basic high school biology or if it prefers you ve had at least a couple of undergraduate level courses in molecular biology and genetics.That being said, it was incredibly helpful in updating my understanding of this field As a biology major in the 90s, this field was so nascent that it was barely addressed, let alone studied thoroughly As a teacher of AP Bio in high school today, I needed an update on vertebrate gene regulation in order to be able to competently address the topic in my classroom This book provided exactly that While I won t be teaching most of the advanced details in this book, I will be adjusting a few critical things to ensure alignment with today s knowledge.Even better, it reminded me why I have always found genetics so fascinating It s even so now than it was 25 years ago As so often happens in emerging fields, each intriguing answer leads to dozens questions If you think the way a basic prokaryotic operon works is pretty cool, learning about mammalian epigenetic gene regulation will make your brain geek out with intellectual joy. This is my first book on Epigenetics and it s fascinating how different situations, actions, or experiences in our lives can affect our cells Events that happened to our parents, grandparents, and so forth can also affect our cells in ways science is just starting to understand I liked how Nessa Carey laid out the book She starts with a history and some examples of epigenetics She then discusses cells and how they work and how epigenetics is contributing to understanding diseases such as cancer and Alzheimer s She looks at why identical twins are not truly identical at the cellular level and how psychological trauma at an early age can affect us She finishes the book with what we can expect to see in the future from the field of Epigenetics.I learned a lot from this book and want to learn about this topic I did find it difficult to stay engaged, partly because of Carey s abundant use of adverbs, and partly because I m not well versed in biology Maybe if I had a better basic understanding before going in it s been a long time since I took a college biology course it would ve been engaging for me Overall a great introduction to the field. This is a fine introduction to the topic by an extremely knowledgeable researcher Carey tries to make it all very accessible to the novice, but in fact it presupposes a fair amount of understanding of molecular biology, especially of how DNA and RNA work, and at least a rudimentary understanding of protein folding and heredity.I felt there was too great an emphasis on epigenetic causes of human diseases, about which fairly little is known except for a few rare but well explored cases Therefore, I only skimmed the last few chapters.I read this book and also took a Coursera online course in epigenetics, but I still have no clear idea about the relationship between genetics and epigenetics as applied to inheritance patterns I cannot imagine how to add epigenetic dynamics to the biological models I work with, or if they make any difference at all to population biology. This is an outstanding introduction to the rapidly advancing field of epigenetics, which is of profound importance for evolutionary biology, trait inheritance and gene therapy endeavors The author excels in making the very complex understandable and her personal comments on main researches add a human dimension Lacking is discourse on possible misuses of epigenetic insights and perhaps some speculations on the uses of epigenetics for steering the future of human evolution But these are not really essential in this book, though I would love to know the views of the author Disturbing is a rather narrow epistemology of science It is not true that science must avoid domains where it is impossible to develop the testable hypotheses that are the cornerstone of all scientific enquiry p.235 , Leaving aside the social sciences, large parts of astronomy, evolutionary psychology and also the science of evolution are far from fully satisfying this requirement Abduction, as proposed by Charles Sanders Peirce in his work on the logic of science and expanded later, is ignored The proposed mechanistic models ignore quantum mechanics And, to conclude this list of disturbing statements, I wonder how the author would elaborate her statement A phenomenon can have a mechanistic basis, without being deterministic p 235 at a workshop on free will attended by philosophers of the mind and brain scientists.The main part of the book on epigenetics deserves five stars and is strongly recommended I choose to ignore superfluous statements irrelevant for the core contents and suggest that readers do so too.Professor Yehezkel Dror Very nicely written layman level intro to Epigenetics Great analogies, good exposition, good emphasis about explaining why discoveries are important are unexpected Read it as an informal textbook to an academic class in Epigenetics Probably got 33% of all the learning from the book and 67% from the class, and I have a suspicion the the basic lessons of the book will stick than the forest of class details about what protein acetylates what unit of the histone.Would possibly be nice to expose a little of the molecular detail, without frightening horses and small children.

About the Author: Nessa Carey

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